Active Ingredient: Marbofloxacin

Optimal distribution within tissues and cells
Fast bactericidal activity
Excellent safety profile
1 ml contains: marbofloxacin 100 mg.

Injectable solution.

Marbofloxacin is a synthetic bactericidal antimicrobial agent belonging to the fluoroquinolones group, which acts through inhibition of DNA gyrase.
It is efficacious against numerous Gram-positive bacteria (particularly Staphylococcus spp.), Gram-negative bacteria (Escherichia coli, Pasteurella multocida, Mannheimia haemolytica and Actinobacillus pleuropneumoniae) and Mycoplasmas (Mycoplasma bovis, Mycoplasma hyopneumoniae). After subcutaneous or intramuscular administration in cattle and in swine, at the recommended dose of 2 mg/kg bw, marbofloxacin is rapidly absorbed and reaches its maximum plasma concentration of 1.5 µg/ml in less than one hour.
Its bioavailability is almost 100%. Marbofloxacin binds weakly to plasma proteins (less than 10% in swine and less than 30% in cattle) and distributes extensively throughout the organism.
In most tissues (liver, kidneys, skin, lungs, bladder, uterus) it reaches concentrations greater than those in the plasma. Following intramuscular administration in lactating cows, marbofloxacin reaches maximum concentrations in the milk of 1.02 µg/ml (Cmax after the first administration) in 2.5 hours. Marbofloxacin is eliminated slowly in preruminant calves (t½ = 5-9 hours) and in swine (t½ = 8-10 hours), more rapidly in ruminant cattle (t½ = 4-7 hours), principally in active form in the urine and in the feces.

Cattle: treatment of respiratory infections caused by sensitive strains of Pasteurella multocida, Mannheimia (Pasteurella) haemolytica and Mycoplasma bovis; treatment of acute mastitis caused by strains of E. coli sensitive to marbofloxacin during the lactation period.
Sows: treatment of Metritis-Mastitis-Agalactia syndrome caused by bacterial strains sensitive to marbofloxacin.


The recommended daily dose is 2 mg of marbofloxacin/kg bw (equivalent to 1 ml of Aristos 10 per 50 kg bw).
Treatment of respiratory infections: 1 ml/50 kg bw in a single daily injection by the subcutaneous or intramuscular route for 3-5 consecutive days.
Treatment of acute mastitis: 1 ml/50 kg bw in a single daily injection by the subcutaneous or intramuscular route for 3 consecutive days. The first administration can also be performed by the intravenous route.
1 ml/50 kg bw in a single daily injection by the intramuscular route for 3 consecutive days.
2 ml/25 kg bw one shot by the intramuscular route.


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