ARISTOS 2

COMPOSITION

1 ml contains: marbofloxacin 20 mg.

PHARMACEUTICAL FORM

Injectable solution.

TARGET SPECIES

Cattle

PROPERTIES

Marbofloxacin is a synthetic bactericidal antimicrobial agent belonging to the fluoroquinolones group, which acts through inhibition of DNA gyrase.
It is efficacious against numerous Gram-positive bacteria (particularly Staphylococcus spp.), Gram-negative bacteria (Escherichia coli, Pasteurella multocida, Mannheimia (Pasteurella) haemolytica and Actinobacillus pleuropneumoniae) and Mycoplasmas (Mycoplasma bovis, Mycoplasma hyopneumoniae). After subcutaneous or intramuscular administration in cattle and in swine, at the recommended dose of 2 mg/kg bw, marbofloxacin is rapidly absorbed and reaches its maximum plasma concentration of 1.5 µg/ml in less than one hour.
Its bioavailability reaches almost 100%. Marbofloxacin binds weakly to plasma proteins (less than 10% in swine and less than 30% in cattle) and distributes extensively throughout the organism.
In most tissues (liver, kidneys, skin, lungs, bladder, uterus) it reaches concentrations greater than those in the plasma. Marbofloxacin is eliminated slowly in preruminant calves (t½ 5-9 hours) and in swine (t½ = 8-10 hours), more rapidly in ruminant cattle (t½ = 4-7 hours), principally in active form in the urine and in the feces.

INDICATIONS

Preruminant and ruminant calves: treatment of respiratory infections caused by sensitive strains of Pasteurella multocida, Mannheimia (Pasteurella) haemolytica and Mycoplasma bovis.
Swine: treatment of respiratory infections caused by sensitive strains of Actinobacillus pleuropneumoniae, Mycoplasma hyopneumoniae, Pasteurella multocida.

ADMINISTRATION

DOSAGE