BICORMICINA L.A.

COMPOSITION

1 ml contains: benzylpenicillin procaine 125,000 IU, benzylpenicillin benzathine 125,000 IU, dihydrostreptomycin sulphate 250 mg, dexamethasone sodium phosphate 0.2 mg, dexamethasone 21-isonicotinate 0.2 mg.

PHARMACEUTICAL FORM

Injectable suspension.

TARGET SPECIES

Cattle, sheep, goats, horses, dogs and cats.

PROPERTIES

Bicormicina L.A. is an association of penicillins, dihydrostreptomycin and dexamethasones formulated in such a manner as to obtain long-lasting effect, combined however with rapid action both against the symptoms and the causes of disease. Activity is modulated over time owing to the different pharmacokinetics of two benzylpenicillin salts and two dexamethasone esters: benzylpenicillin procaine and dexamethasone sodium phosphate, which show rapid, short-term activity and benzylpenicillin benzathine and dexamethasone-21-isonicotinate, which produce a slower, more prolonged action.
Dexamethasone sodium phosphate already shows its maximum concentration in the blood 20 minutes after injection, remaining at high levels for 10-12 hours. Benzylpenicillin procaine reaches its peak in the blood 6 hours after administration, with a gradual decrease over 24 hours. Dexamethasone-21-isonicotinate reaches maximum concentration after 14-18 hours, remaining at effective levels in the blood up to 48 hours after injection. Benzylpenicillin benzathine reaches its blood peak 24 hour after administration, thus contributing to maintenance of a high total penicillins curve for up to 48 hours after treatment.

INDICATIONS

The diseases for which such treatment is indicated are the following: tonsillitis, tracheitis, bronchitis, bronchopneumonia, pleuritis; arthritis, arthrosynovitis, tendonitis, tendosynovitis; infections caused by the presence of foreign bodies, enteritis, peritonitis; actinogranulomatosis, dermatitis, pyoderma, abscesses; foot infections, necrotic pododermatitis; gangrenous mastitis, mastitis of streptococcal and staphylococcal origin; urinary tract infections, metritis, metroperitonitis, MMA; septicaemia, toxaemia; traumatic and post-operative cuts and wounds.

ADMINISTRATION

DOSAGE