Description
Active Ingredient: Ampicillin sodium-bromhexine hydrochloride
KEY POINTS
- Wide distribution in the respiratory tract
- Rapid activation of mucociliary clearance
- Prompt recovery of the treated animals
COMPOSITION
1 ml of reconstituted solution contains: ampicillin sodium 213 mg equivalent to ampicillin 200 mg, bromhexine hydrochloride 1.5 mg.
PHARMACEUTICAL FORM
Sterile powder for injection.
TARGET SPECIES
Cattle, horses, poultry
PROPERTIES
Ampicillin is a semi-synthetic penicillin endowed with bactericidal antimicrobial activity against Gram-positive microorganisms (Streptococcus spp., non-penicillinase producing Staphylococcus spp., Clostridium spp. and Bacillus anthracis) and Gram-negative microorganisms (E. coli, Proteus spp., Klebsiella spp., Haemophilus spp., Salmonella spp., Pasteurella spp.).
Activity is high during reproductive phase of pathogenous microorganisms through inhibition of wall mucopeptide synthesis.
The blood peak for ampicillin following intramuscular or subcutaneous administration is reached within 1 hour, irrespectively of animal species.
Serum protein binding is very low and the drug distributes readily to all tissues and organic fluids.
Bromhexine liquefies the mucus involved in bronchial secretion and is endowed with antitoxigenic action and respiratory stimulant action.
Bromhexine amplifies antimicrobial efficacy both through increase of local antibiotic concentration and through closer contact between antibiotic and bacteria.
INDICATIONS
Treatment of inflammatory infections of the respiratory apparatus even in presence of exudates.
In particular: rhinitis, laryngotracheitis, acute/chronic bronchitis, acute/chronic broncho-pneumonia, bacterial diseases secondary to viral infections and lung parasite infestations.
Poultry: coryza, laryngotracheitis, chronic respiratory disease.
ADMINISTRATION
IV; IM.
DOSAGE
Calves, foals, piglets: 1-1.2 ml/10 kg bw/day.
Swine: 0.8-1 ml/10 kg bw/day.
Poultry: 0.15 ml/kg bw/day.
Administer via IV or IM route preferably dividing daily dosage in two administrations.
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