Active Ingredient: Thiamphenicol glycinate acetylcysteinate
- Two active ingredients in one single molecule
- Both antibiotic and mucolytic action
- Rapidly clears up respiratory infections
Each powder vial contains: thiamphenicol glycinate acetylcysteinate 4.05 g (equivalent to thiamphenicol 2.5 g and acetylcysteine 1.15 g. Solvent vial: 20 ml.
Sterile powder for injection.
Cattle and turkeys.
Thiamphenicol glycinate acetylcysteinate breaks down, in the animal organism, into equimolecular doses of thiamphenicol and acetylcysteine.
Thiamphenicol is a broad-spectrum antibiotic, active against Gram-positive bacteria (Clostridium spp., Corynebacterium spp., Erysipelothrix rhusiopathiae, Haemophilus pleuropneumoniae, Lysteria spp., Staphylococcus spp., Streptococcus spp.) and Gram-negative bacteria (Bordetella spp., Brucella spp., Klebsiella spp., Pasteurella spp., Shigella spp., anaerobic Treponema spp.), mycoplasmas and rickettsiae. Its mechanism of action consists of blockage of protein biosynthesis, with a bacteriostatic activity becoming bactericidal at concentrations slightly higher than the MIC.
It is not negatively affected by the presence of pus, nor the action of beta-lactamase and nitroreductase. The onset of bacterial resistance is very rare. Acetylcysteine has mucolytic, antiinflammatory and tissue-tropic properties. Its mucolytic activity is due to its capacity to rupture the disulphide bridges of mucopolysaccharides and the nucleic acid fibres originating from the necrosis of leukocytes, cells of the tissues affected by inflammation and the bacteria. Acetylcysteine therefore liquefies the mucous and mucopurulent secretions constituting a barrier between the antibiotic and the pathogenic microorganisms, thus favouring the distribution of the drug and its contact with the infectious agents.
The antiinflammatory action of acetylcysteine is of the direct type, as it interferes with the release of the chemical mediators of inflammation.
Acetylcysteine has a high tropism for the respiratory system and also shows a bronchospasm-combating effect.
The tissue-trophic action stimulates regeneration of the mucosal epithelia, favouring repair processes.
Calves and adult cattle: shipping fever, bronchitis and bronchopneumonia.
Turkeys: chronic respiratory disease or airsacculitis, infectious sinusitis.
Calves: ½-1 bottle/animal/day, in two administrations with administrations 12 hours apart, for 2-7 days.
Adult cattle: 2-2.5 bottles/animal/day, in two administrations with administrations 12 hours apart, for 3-5 days.
Turkeys: normal subjects: 1-1.5 ml/day for 3 days.
One-month-old giant turkeys: 3-3.5 ml/day for 3 days.