TIRSAN Injection

COMPOSITION

1 ml contains: thiamphenicol 250 mg.

PHARMACEUTICAL FORM

Injectable solution.

TARGET SPECIES

Cattle, sheep, goats

PROPERTIES

Tirsan contains the biologically active and enantiomerically pure form of thiamphenicol.
Thiamphenicol is an antibiotic possessing a chemical structure very similar to that of chloramphenicol, from which it differs in the substitution of the p-nitro group with a p-methylsulphonyl radical. This substitution renders thiamphenicol free from the toxicological effects.
Thiamphenicol is a broad spectrum antibiotic, active against both Gram-positive and Gram-negative bacteria, anaerobes, chlamydiae, mycoplasmas, rickettsiae and some protozoa. Thiamphenicol shows a powerful bacteriostatic-bactericidal effect, even in infections characterized by a purulent component or by mucous hypersecretion. It is rapidly absorbed and, owing to the low percentage of binding to plasma proteins and high liposolubility, it is widely distributed throughout the organism, where it reaches concentrations equal, or superior, to those in the blood.
Unlike other antibiotics, thiamphenicol is practically non-metabolized and persists biologically active, exercising a prolonged antibiotic action. It is eliminated in active form via the urine and the bile, demonstrating high efficacy even in urinary and intestinal infections.
Thiamphenicol shows an excellent local tolerance and is free from risks of toxicity.

INDICATIONS

Septic infections caused by sensitive microorganisms.  Use is advised, in particular, in septicemias caused by Salmonella spp., E. coli, Pasteurella spp., Clostridium spp. etc., in intestinal infections and in bronchopneumonia and pneumonia caused by shipping, in secondary infections following viral diseases, in infections of the urinary tract, in metritis, pyometra and mastitis, in hoof infections, in dermatitis.

ADMINISTRATION

DOSAGE