Description
Active Ingredient: Doxycycline hyclate
KEY POINTS
- High solubility of the formulation
- Rapid and total absorption, with bioavailability close to 100%
- Broad antibacterial spectrum, in many cases doxycycline is also active against pathogens resistant to other antibiotics
- Very low efficacious dosages (10 times lower than oxytetracycline)
COMPOSITION
1 g of powder contains: doxycycline (as doxycycline hyclate) 300 mg.
PHARMACEUTICAL FORM
Oral powder.
TARGET SPECIES
Calf.
PROPERTIES
Doxycycline is a long-acting second generation tetracycline. It shows a broad spectrum of action which includes Gram-positive and Gram-negative bacteria, chlamydiae, rickettsiae, mycoplasmas and spirochetes.
It acts principally bacteriostatically, inhibiting bacterial protein synthesis.
Following oral administration, doxycycline is rapidly absorbed, with bioavailability values which can reach 95-100%. It binds extensively to plasma proteins and, thanks to its high lipophilia, distributes more widely than other tetracyclines.
In particular, high concentrations are reached in the heart, kidney, lungs, muscle, pleural fluid, bronchial secretions, sputum, bile, saliva, synovial fluid, ascitic fluid, and aqueous and vitreous humor. Doxycycline differs from the other tetracyclines also in its route of elimination. The drug is primarily excreted into the feces via non-biliary routes in an inactive form, and only partially through the kidneys.
Fatrocycline is characterized by a very long stability: 2 months after first broaching of the container; 24 hours after solubilization in the drinking water.
INDICATIONS
Swine: infections due to Gram-positive and Gram-negative bacteria and mycoplasmas sensitive to doxycycline, particularly respiratory infections due to Pasteurella multocida, Bordetella bronchiseptica, Actinobacillus pleuropneumoniae, Haemophilus parasuis and Mycoplasma hyopneumoniae.
Calf: respiratory infections caused by both Gram+ positive and Gram- negative bacteria, particularly some doxycycline sensitive strains of Mannheimia haemolytica and Pasteurella multocida.
ADMINISTRATION
OS.
DOSAGE
Calf: 0,33 g g of Fatrocycline/10 kg bw/day (equivalent to 10 mg of doxycycline/kg bw day).
Dissolve the recommended dose in the drinking water on the basis of the weight and water consumption of the animals.
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